LOS40 Mexico is the Mexican branch of the international LOS40 radio network, broadcasting from Mexico City. Launched in 2004, it has become one of the country's leading pop music stations, targeting a young audience aged 12-30. The station plays contemporary hits in both Spanish and English, featuring a mix of Latin American, American, and European artists.

LOS40 Mexico offers a variety of popular programs, including:

• "¡Ya Párate!" - A morning show hosted by Facundo, Alexita Garza, and Iñaki
• "La Corneta" - A comedy and entertainment program
• "El Tlacuache" - A late-night show with Faisy, Gabo Ramos, and El Diablito
• "El Brunch" - A weekend lifestyle and culture program

The station also organizes major music events like "El Evento 40," an annual concert featuring top national and international artists. LOS40 Mexico maintains a strong digital presence, offering streaming services, mobile apps, and podcasts to complement its traditional radio broadcasting.