VRT Radio 2 Oost-Vlaanderen is the East Flanders regional station of Radio 2, the Flemish public broadcaster VRT's popular music and information channel. Broadcasting from Ghent, it offers a mix of local news, weather, traffic updates, and popular music with a focus on Dutch-language and Flemish productions. The station's regional programming includes daily local news bulletins and a dedicated midday show called "De Middag" on weekdays from 12-1 PM.

Radio 2 Oost-Vlaanderen traces its origins back to 1944, with the current studio building on Martelaarslaan in Ghent inaugurated in 1976. Over the years, it has produced many popular Radio 2 programs like the Flemish Top 10, Top 30, and shows such as "De Zoete Inval" and "Bistro en Co."

The station aims to be close to its listeners, covering topics relevant to daily life in East Flanders while also addressing broader social issues. Its mix of familiar music, local content, and information helps make Radio 2 the most listened-to radio network in Flanders.