KIIS 106.5 FM is a commercial radio station broadcasting in Sydney, New South Wales, Australia. It is the flagship station of the KIIS Network, owned by ARN Media. The station began as 2UW in 1925 on the AM band before converting to FM in 1994 as Mix 106.5. In 2014, it was rebranded as KIIS 1065, adopting its current name and format.

KIIS 106.5 plays contemporary hit radio (CHR) and hot adult contemporary music, targeting listeners aged 25-54. Its flagship program is "The Kyle and Jackie O Show", hosted by Kyle Sandilands and Jackie 'O' Henderson, which airs weekday mornings. Other popular shows include "Will & Woody" in the afternoon drive slot.

The station is known for playing the latest hit music, celebrity interviews, and engaging content. It has become one of Sydney's top-rated radio stations since its relaunch as KIIS in 2014, particularly dominating the breakfast timeslot with Kyle and Jackie O.